Olfactory heterogeneity in LRRK2 related Parkinsonism
Identifieur interne : 000615 ( Main/Exploration ); précédent : 000614; suivant : 000616Olfactory heterogeneity in LRRK2 related Parkinsonism
Auteurs : Laura Silveira-Moriyama [Royaume-Uni] ; Renato Pupi Munhoz [Brésil] ; Margarete De J. Carvalho [Brésil] ; Salmo Raskin [Brésil] ; Ekaterina Rogaeva [Canada] ; Patricia De C. Aguiar [Brésil] ; Rodrigo A. Bressan [Brésil] ; Andre C. Felicio [Brésil] ; Orlando G. P. Barsottini [Brésil] ; Luiz Augusto F. Andrade [Brésil] ; Hsin F. Chien [Brésil] ; Vincenzo Bonifati [Pays-Bas] ; Egberto R. Barbosa [Brésil] ; Helio A. Teive [Brésil] ; Andrew Lees (neurologue) [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
English descriptors
- KwdEn :
- LRRK2, PARK8, olfaction, parkinsonism, smell.
Abstract
LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. The mean SS‐16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for β = −4.7 to −1.7) and lower than in controls (p = 0.007, 95% CI for β = +0.6 to +3.6). In the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.23325
Affiliations:
- Brésil, Canada, Pays-Bas, Royaume-Uni
- Angleterre, Grand Londres, Hollande-Méridionale, Ontario, Paraná (État), État de São Paulo
- Londres, Rotterdam, São Paulo, Toronto
- National Hospital for Neurology and Neurosurgery, Université de Toronto
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Olfactory heterogeneity in LRRK2 related Parkinsonism</title><author><name sortKey="Silveira Oriyama, Laura" sort="Silveira Oriyama, Laura" uniqKey="Silveira Oriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name></author><author><name sortKey="Munhoz, Renato Pupi" sort="Munhoz, Renato Pupi" uniqKey="Munhoz R" first="Renato Pupi" last="Munhoz">Renato Pupi Munhoz</name></author><author><name sortKey="De J Carvalho, Margarete" sort="De J Carvalho, Margarete" uniqKey="De J Carvalho M" first="Margarete" last="De J. Carvalho">Margarete De J. Carvalho</name></author><author><name sortKey="Raskin, Salmo" sort="Raskin, Salmo" uniqKey="Raskin S" first="Salmo" last="Raskin">Salmo Raskin</name></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name></author><author><name sortKey="De C Aguiar, Patricia" sort="De C Aguiar, Patricia" uniqKey="De C Aguiar P" first="Patricia" last="De C. Aguiar">Patricia De C. Aguiar</name></author><author><name sortKey="Bressan, Rodrigo A" sort="Bressan, Rodrigo A" uniqKey="Bressan R" first="Rodrigo A." last="Bressan">Rodrigo A. Bressan</name></author><author><name sortKey="Felicio, Andre C" sort="Felicio, Andre C" uniqKey="Felicio A" first="Andre C." last="Felicio">Andre C. Felicio</name></author><author><name sortKey="Barsottini, Orlando G P" sort="Barsottini, Orlando G P" uniqKey="Barsottini O" first="Orlando G. P." last="Barsottini">Orlando G. P. Barsottini</name></author><author><name sortKey="Andrade, Luiz Augusto F" sort="Andrade, Luiz Augusto F" uniqKey="Andrade L" first="Luiz Augusto F." last="Andrade">Luiz Augusto F. Andrade</name></author><author><name sortKey="Chien, Hsin F" sort="Chien, Hsin F" uniqKey="Chien H" first="Hsin F." last="Chien">Hsin F. Chien</name></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name></author><author><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name></author><author><name sortKey="Teive, Helio A" sort="Teive, Helio A" uniqKey="Teive H" first="Helio A." last="Teive">Helio A. Teive</name></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:812BDDD70A7C5A82FA206880E00F606B2AC14CD9</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.23325</idno><idno type="url">https://api.istex.fr/document/812BDDD70A7C5A82FA206880E00F606B2AC14CD9/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002737</idno><idno type="wicri:Area/Main/Curation">002394</idno><idno type="wicri:Area/Main/Exploration">000615</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Olfactory heterogeneity in LRRK2 related Parkinsonism</title><author><name sortKey="Silveira Oriyama, Laura" sort="Silveira Oriyama, Laura" uniqKey="Silveira Oriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Munhoz, Renato Pupi" sort="Munhoz, Renato Pupi" uniqKey="Munhoz R" first="Renato Pupi" last="Munhoz">Renato Pupi Munhoz</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR</wicri:regionArea><placeName><region type="state">Paraná (État)</region></placeName></affiliation></author><author><name sortKey="De J Carvalho, Margarete" sort="De J Carvalho, Margarete" uniqKey="De J Carvalho M" first="Margarete" last="De J. Carvalho">Margarete De J. Carvalho</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Raskin, Salmo" sort="Raskin, Salmo" uniqKey="Raskin S" first="Salmo" last="Raskin">Salmo Raskin</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR</wicri:regionArea><placeName><region type="state">Paraná (État)</region></placeName></affiliation></author><author><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="De C Aguiar, Patricia" sort="De C Aguiar, Patricia" uniqKey="De C Aguiar P" first="Patricia" last="De C. Aguiar">Patricia De C. Aguiar</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Bressan, Rodrigo A" sort="Bressan, Rodrigo A" uniqKey="Bressan R" first="Rodrigo A." last="Bressan">Rodrigo A. Bressan</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Felicio, Andre C" sort="Felicio, Andre C" uniqKey="Felicio A" first="Andre C." last="Felicio">Andre C. Felicio</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Interdisciplinar de Neurosciencias Clínicas ‐ LiNC, Universidade Federal de Sao Paulo, UNIFESP, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Barsottini, Orlando G P" sort="Barsottini, Orlando G P" uniqKey="Barsottini O" first="Orlando G. P." last="Barsottini">Orlando G. P. Barsottini</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology and Neurosurgery, Universidade Federal de São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Andrade, Luiz Augusto F" sort="Andrade, Luiz Augusto F" uniqKey="Andrade L" first="Luiz Augusto F." last="Andrade">Luiz Augusto F. Andrade</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto do Cérebro ‐ Instituto Israelita de Ensino e Pesquisa Albert Einstein, Hospital Israelita Albert Einstein, São Paulo‐SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Chien, Hsin F" sort="Chien, Hsin F" uniqKey="Chien H" first="Hsin F." last="Chien">Hsin F. Chien</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Neurology, University of Sao Paulo School of Medicine, Sao Paulo‐SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Teive, Helio A" sort="Teive, Helio A" uniqKey="Teive H" first="Helio A." last="Teive">Helio A. Teive</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Movement Disorders Unit, Neurology Service, Internal Medicine Department Hospital de Clínicas, Federal University of Paraná, Curitiba‐PR</wicri:regionArea><placeName><region type="state">Paraná (État)</region></placeName></affiliation></author><author><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name><affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Reta Lila Weston Institute of Neurological Studies, UCL Institute of Neurology, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName>National Hospital for Neurology and Neurosurgery</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-12-15">2010-12-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2879">2879</biblScope><biblScope unit="page" to="2883">2883</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">812BDDD70A7C5A82FA206880E00F606B2AC14CD9</idno><idno type="DOI">10.1002/mds.23325</idno><idno type="ArticleID">MDS23325</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>LRRK2</term><term>PARK8</term><term>olfaction</term><term>parkinsonism</term><term>smell</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">LRRK2 mutations can cause familial and sporadic Parkinson's disease (PD) with Lewy‐body pathology at post‐mortem. Studies of olfaction in LRRK2 are sparse and incongruent. We applied a previously validated translation of the 16 item smell identification test from Sniffin' Sticks (SS‐16) to 14 parkinsonian carriers of heterozygous G2019S LRRK2 mutation and compared with 106 PD patients and 118 healthy controls. The mean SS‐16 score in LRRK2 was higher than in PD (p < 0.001, 95% CI for β = −4.7 to −1.7) and lower than in controls (p = 0.007, 95% CI for β = +0.6 to +3.6). In the LRRK2 group, subjects with low scores had significantly more dyskinesia. They also had younger age of onset, longer disease duration, and reported less frequently a family history of PD, but none of these other differences reached significance. Odor identification is diminished in LRRK2 parkinsonism but not to the same extent as in idiopathic PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Brésil</li><li>Canada</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Ontario</li><li>Paraná (État)</li><li>État de São Paulo</li></region><settlement><li>Londres</li><li>Rotterdam</li><li>São Paulo</li><li>Toronto</li></settlement><orgName><li>National Hospital for Neurology and Neurosurgery</li><li>Université de Toronto</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Silveira Oriyama, Laura" sort="Silveira Oriyama, Laura" uniqKey="Silveira Oriyama L" first="Laura" last="Silveira-Moriyama">Laura Silveira-Moriyama</name></region><name sortKey="Lees, Andrew J" sort="Lees, Andrew J" uniqKey="Lees A" first="Andrew J." last="Lees">Andrew Lees (neurologue)</name></country><country name="Brésil"><region name="Paraná (État)"><name sortKey="Munhoz, Renato Pupi" sort="Munhoz, Renato Pupi" uniqKey="Munhoz R" first="Renato Pupi" last="Munhoz">Renato Pupi Munhoz</name></region><name sortKey="Andrade, Luiz Augusto F" sort="Andrade, Luiz Augusto F" uniqKey="Andrade L" first="Luiz Augusto F." last="Andrade">Luiz Augusto F. Andrade</name><name sortKey="Barbosa, Egberto R" sort="Barbosa, Egberto R" uniqKey="Barbosa E" first="Egberto R." last="Barbosa">Egberto R. Barbosa</name><name sortKey="Barsottini, Orlando G P" sort="Barsottini, Orlando G P" uniqKey="Barsottini O" first="Orlando G. P." last="Barsottini">Orlando G. P. Barsottini</name><name sortKey="Bressan, Rodrigo A" sort="Bressan, Rodrigo A" uniqKey="Bressan R" first="Rodrigo A." last="Bressan">Rodrigo A. Bressan</name><name sortKey="Bressan, Rodrigo A" sort="Bressan, Rodrigo A" uniqKey="Bressan R" first="Rodrigo A." last="Bressan">Rodrigo A. Bressan</name><name sortKey="Chien, Hsin F" sort="Chien, Hsin F" uniqKey="Chien H" first="Hsin F." last="Chien">Hsin F. Chien</name><name sortKey="De C Aguiar, Patricia" sort="De C Aguiar, Patricia" uniqKey="De C Aguiar P" first="Patricia" last="De C. Aguiar">Patricia De C. Aguiar</name><name sortKey="De J Carvalho, Margarete" sort="De J Carvalho, Margarete" uniqKey="De J Carvalho M" first="Margarete" last="De J. Carvalho">Margarete De J. Carvalho</name><name sortKey="Felicio, Andre C" sort="Felicio, Andre C" uniqKey="Felicio A" first="Andre C." last="Felicio">Andre C. Felicio</name><name sortKey="Felicio, Andre C" sort="Felicio, Andre C" uniqKey="Felicio A" first="Andre C." last="Felicio">Andre C. Felicio</name><name sortKey="Felicio, Andre C" sort="Felicio, Andre C" uniqKey="Felicio A" first="Andre C." last="Felicio">Andre C. Felicio</name><name sortKey="Raskin, Salmo" sort="Raskin, Salmo" uniqKey="Raskin S" first="Salmo" last="Raskin">Salmo Raskin</name><name sortKey="Teive, Helio A" sort="Teive, Helio A" uniqKey="Teive H" first="Helio A." last="Teive">Helio A. Teive</name></country><country name="Canada"><region name="Ontario"><name sortKey="Rogaeva, Ekaterina" sort="Rogaeva, Ekaterina" uniqKey="Rogaeva E" first="Ekaterina" last="Rogaeva">Ekaterina Rogaeva</name></region></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000615 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000615 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:812BDDD70A7C5A82FA206880E00F606B2AC14CD9
|texte= Olfactory heterogeneity in LRRK2 related Parkinsonism
}}
| This area was generated with Dilib version V0.6.23. |  |